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Artiss Duploject

Generic name: fibrin sealant topicalFYE-brin-SEE-lant-TOP-i-kal ]
Brand names: Artiss, Tisseel, Artiss Duo Set, Artiss Duploject, Tisseel Duploject Kit, Tisseel Valupak Kit
Drug class: Miscellaneous coagulation modifiers

Medically reviewed by on Aug 1, 2023. Written by Cerner Multum.

What is Artiss Duploject?

Fibrin sealant is made of two substances from human plasma that work together to help your blood clot.

Artiss Duploject is used to help control bleeding during surgery when other ways to close a wound or incision (such as stitches, bands, or heat) cannot be used. This medicine may also be used to prevent leaks from a wound left in stomach tissue after a colostomy is removed.

Artiss Duploject is sometimes used to help skin tissues stick together during skin graft procedures or cosmetic surgery.

Artiss Duploject may also be used for purposes not listed in this medication guide.

Artiss Duploject side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, warmth, redness, numbness, tingly feeling; nausea, vomiting, feeling light-headed, fast or slow heartbeats; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.

Fibrin sealant is sometimes applied with a spray device that uses gas pressure. High pressure may cause the release of air or gas under the skin tissues, where it can then travel throughout the body. This may be more likely when high pressure settings are improperly used by a healthcare provider during the spray application of fibrin sealant. Air or gas trapped within the body can cause serious or life-threatening effects. Talk with your doctor about this risk.

Tell your caregivers at once if you have:

Common side effects of Artiss Duploject may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not be treated with Artiss Duploject if you are allergic to cows or products made from cows.

Before taking this medicine

You should not be treated with Artiss Duploject if you are allergic to cows or products made from cows.

It is not known whether Artiss Duploject will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether fibrin sealant topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Artiss Duploject?

Artiss Duploject can be sprayed or dripped onto the affected skin or surgical area. Artiss Duploject is applied by a healthcare professional in a surgical or clinical setting.

Artiss Duploject is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Some people develop symptoms of a viral infection after being treated with Artiss Duploject. Call your doctor if you have flu-like symptoms such as fever, chills, drowsiness, or a runny nose. You may also have joint pain and a skin rash about 2 weeks after the start of your flu symptoms.

What happens if I miss a dose?

Because you will receive Artiss Duploject in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since Artiss Duploject is applied by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after being treated with Artiss Duploject?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Artiss Duploject?

It is not likely that other drugs you take orally or inject will have an effect on topically applied fibrin sealant. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.