How effective is Orladeyo?
Clinical studies show that Orladeyo (berotralstat) effectively reduces hereditary angioedema (HAE) attacks:
- In a study with adults and teens, Orladeyo reduced monthly HAE attacks from 3.1 to 1.3 after six months of treatment. In comparison, those on a placebo saw a smaller reduction, from 2.9 to 2.4 attacks per month.
- Over two years, people taking Orladeyo 150 mg once daily experienced a 91% reduction in their HAE attack rate. Attacks decreased from 2.8 per month before treatment to 0.3 per month after two years.
- A decrease in HAE attacks was observed within the first month of treatment.
How Does Orladeyo Work?
Orlando is a plasma kallikrein inhibitor that helps prevent hereditary angioedema (HAE) attacks in people 12 years and older. It works by:
- Blocking plasma kallikrein, a protein involved in the production of bradykinin, which causes swelling and pain.
- Reducing bradykinin levels, helping to prevent HAE attacks before they occur.
Is Orladeyo FDA-Approved?
Yes, Orlando is an FDA-approved medication. The U.S. Food and Drug Administration (FDA) approved it on December 3, 2020, based on a 24-week clinical trial involving 120 adults and teens.
Orladeyo is not known to be safe or effective in children under 12 years old.
This is not all the information you need to know about Orladeyo (berotralstat) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
References
BioCryst. 2024. Why Orladeyo? Accessed 10/23/2024 at https://orladeyo.com/hae-treatment
Orladeyo [package insert]. Updated November 2023. BioCryst Pharmaceuticals Inc. Accessed 10/23/2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3527ece1-e7e0-40b1-b0c5-6baeb0deabeb
U.S. Food and Drug Administration. 2020. Drug Trials Snapshot: Orladeyo. Accessed 10/23/2024 at https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshot-orladeyo
See also:
Aimovig
Learn about Aimovig (erenumab-aooe) a once-monthly, injectable medication that can be ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Haegarda
Haegarda is an injectable protein replacement therapy that prevents swelling and attacks in ...
Nurtec ODT
Nurtec ODT (rimegepant) is used to treat acute migraines and prevent episodic migraines, by ...
Vyepti
Vyepti (eptinezumab-jjmr) is used for the preventive treatment of migraine. Includes Vyepti ...
Depakote
Depakote is used to treat various types of seizure disorders. Learn about side effects ...
Topamax
Topamax (topiramate) is used to prevent seizures in adults and children and to prevent migraine ...
Emgality
Emgality (galcanezumab-gnlm) is a CGRP antagonist for the preventive treatment of migraine and for ...
Inderal
Inderal (propranolol) is used to treat angina, high blood pressure and heart rhythm disorders ...
Related medical questions
- How is Takhzyro injected/administered?
- What is Takhzyro used for and how does it work?
- What is Cinryze used for and how does it work?
- How do you administer/inject Firazyr?
- What type of drug is Takhzyro?
Drug information
- Orladeyo Information for Consumers
- Orladeyo prescribing info & package insert (for Health Professionals)
- Side Effects of Orladeyo (detailed)
- Orladeyo user reviews (3)
Related support groups
- Orladeyo (1 questions, 3 members)
- Hereditary Angioedema (6 questions, 15 members)