How is fabrazyme administered/infused?

Fabrazyme is given by intravenous infusion every two weeks by a healthcare provider. How long the infusion of Fabrazyme takes depends on how well you tolerate Fabrazyme and your weight.

Fabrazyme can cause infusion-associated reactions, such as chills, vomiting, low blood pressure, or paresthesia (burning or prickling sensations, usually in the hands), so your healthcare provider will start the infusion off slowly, at around 15mg per hour. This rate may be increased if you tolerate the infusion well and you weigh more than 30kg.

The minimum infusion duration for people weighing more than 30kg is 1.5 hours.

For people weighing less than 30kg, the maximum infusion rate is 15mg/hour, which means for a child weighing 20kg the infusion will take at least 80 minutes.

Fabrazyme is a recombinant human α-galactosidase A enzyme called agalsidase beta that may be used to treat Fabry disease in adults and children aged 2 years and older. It has the same amino acid sequence as the naturally-occurring enzyme called alpha-galactosidase A (or alpha-GAL).

See also:

Related medical questions

• How does Fabrazyme enzyme replacement therapy work?
• What is an amenable mutation?
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Drug information

• Fabrazyme Information for Consumers
• Fabrazyme prescribing info & package insert (for Health Professionals)
• Side Effects of Fabrazyme (detailed)

Related support groups

• Fabrazyme (2 questions, 3 members)
• Fabry Disease (4 questions, 3 members)

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