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In some countries, this medicine may only be approved for veterinary use.



CAS registry number (Chemical Abstracts Service)


Therapeutic Categories



Chemical Names

Mixture of Spinosyn A and Spinosyn D

Spinosyn A:1H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-metyl-α-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimetylamino)tetrahydro-6-metyl-2H-pyran-2-yl]oxy]-9-etyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-metyl- (USAN)

Spinosyn D:1H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-metyl-α-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimetylamino)tetrahydro-6-metyl-2H-pyran-2-yl]oxy]-9-etyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dime (USAN)

Foreign Name

  • Spinosad (German)

Generic Names

  • Spinosad (OS: USAN)
  • DE-105 (IS)
  • LY-232105 (IS)
  • PP-105 (IS)
  • XDE-105 (IS)

Brand Names

  • Comfortis (veterinary use)
    Elanco, New Zealand; Elanco Animal Health, Australia; Elanco Animal Health, United States; Eli Lilly Benelux, Belgium; Lilly, United Kingdom; Lilly Nederland, Netherlands; Lilly Vet, France; Lilly-Elanco, Italy; Provet, Switzerland
  • Cyrex (Spinosad and Cyromazine (veterinary use))
    Elanco, New Zealand
  • Expo Extinosad (veterinary use)
    Elanco, New Zealand
  • Extinosad (Spinosad and Chlorhexidine (veterinary use))
    Elanco Animal Health, Australia
  • Extinosad (veterinary use)
    Elanco, New Zealand; Elanco, South Africa; Elanco Animal Health, Australia
  • Natroba
    ParaPRO, United States
  • Panoramis (Spinosad and Milbemycin Oxime (veterinary use))
    Elanco, New Zealand; Elanco Animal Health, Australia
  • Spinosad Macoven
    Macoven Pharmaceuticals, United States
  • Trifexis (Spinosad and Milbemycin (veterinary use))
    Elanco Animal Health, United States; Eli Lilly, United Kingdom; Lilly Vet, France; Lilly-Elanco, Italy
  • Trifexis chiens (Spinosad and Milbemycin Oxime (veterinary use))
    Eli Lilly Benelux, Belgium


ISInofficial Synonym
OSOfficial Synonym
USANUnited States Adopted Name

Further information on drug naming conventions: International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.