Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- dacarbazine
- Proleukin (aldesleukin)
Interactions between your drugs
dacarbazine aldesleukin
Applies to: dacarbazine, Proleukin (aldesleukin)
GENERALLY AVOID: Aldesleukin in combination with certain antineoplastic agents (cisplatin, dacarbazine, vinblastine) has been associated with fatal tumor lysis syndrome. Symptoms include hyperkalemia, hyperphosphatasemia, hyperuricemia, hypocalcemia, and acute renal failure. In addition, hypersensitivity reactions requiring medical intervention have been reported with the use of sequential high-dose aldesleukin and dacarbazine or cisplatin. Symptoms occurred within a few hours after chemotherapy administration and included erythema, pruritus, and hypotension.
MANAGEMENT: Concomitant use is not recommended.
References (4)
- (2001) "Product Information. Proleukin (aldesleukin)." Chiron Therapeutics
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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