Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Frindovyx (cyclophosphamide)
- pentostatin
Interactions between your drugs
cycloPHOSphamide pentostatin
Applies to: Frindovyx (cyclophosphamide), pentostatin
MONITOR: Coadministration of pentostatin with cyclophosphamide may enhance the cardiotoxic effects of cyclophosphamide. The mechanism of this interaction has not been delineated. Two cases of fatal cardiovascular collapse have been reported following administration of intravenous pentostatin with high-dose oral cyclophosphamide.
MANAGEMENT: Patients receiving pentostatin and cyclophosphamide should be monitored for development of signs and symptoms of cardiotoxicity including, but not limited to respiratory distress, pulmonary edema, hypotension, hypothermia, and confusion. Some authorities recommend avoiding the use of intravenous pentostatin with high-dose oral cyclophosphamide.
References (4)
- (2001) "Product Information. Cytoxan (cyclophosphamide)." Bristol-Myers Squibb
- (2001) "Product Information. Nipent (pentostatin)." Hospira Inc
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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