Drug Interaction Report
5 potential interactions and/or warnings found for the following 2 drugs:
- cyanocobalamin / folic acid / pyridoxine / strontium gluconate
- phenytoin
Interactions between your drugs
phenytoin folic acid
Applies to: phenytoin, cyanocobalamin / folic acid / pyridoxine / strontium gluconate
Some anticonvulsant medications may reduce the blood levels of folic acid. In addition, folic acid treatment may reduce the blood levels of certain anticonvulsants. Talk to your doctor if you have any questions or concerns. You may need a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience loss of seizure control. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
phenytoin pyridoxine
Applies to: phenytoin, cyanocobalamin / folic acid / pyridoxine / strontium gluconate
Using pyridoxine together with phenytoin may decrease the effects of phenytoin. Contact your doctor if your condition changes or if you experience loss of seizure control. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
phenytoin food
Applies to: phenytoin
Phenytoin levels may decrease when the suspension is given with enteral feedings. This could lead to a loss of seizure control. You could interrupt the feeding for 2 hours before and after the phenytoin dose. Alternatively, you may give the phenytoin suspension diluted in water and flush the tube with water after administration. These would make it easier for your body to absorb the medication. However, this still may not entirely avoid the interaction and may not always be feasible. You should have your phenytoin levels checked upon starting and stopping of enteral feedings. In addition, using phenytoin together with food may alter the effects of phenytoin. Contact your doctor if you experience worsening of seizure control or symptoms of toxicity, including twitching eye movements, slurred speech, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Ask your doctor before making any changes to your therapy.
folic acid food
Applies to: cyanocobalamin / folic acid / pyridoxine / strontium gluconate
Talk to your doctor before using alcohol together with folic acid. Excessive consumption of alcohol may reduce the absorption and increase the elimination of folic acid. Contact your doctor if your symptoms worsen or your condition changes. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
strontium gluconate food
Applies to: cyanocobalamin / folic acid / pyridoxine / strontium gluconate
Strontium gluconate should be taken on an empty stomach 1 hour before or 2 hours after a meal and preferably at bedtime unless otherwise directed by your doctor. You may experience reduced absorption of strontium gluconate in the presence of food or milk. This will make it easier for your body to absorb the medication.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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