Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- cisplatin
- Demadex IV (torsemide)
Interactions between your drugs
CISplatin torsemide
Applies to: cisplatin, Demadex IV (torsemide)
GENERALLY AVOID: The concomitant use of loop diuretics with cisplatin may increase the risk of ototoxicity. Loop diuretics, especially ethacrynic acid and high doses of furosemide, and cisplatin have been individually associated with ototoxicity.
MANAGEMENT: This combination should be avoided unless the potential benefit outweighs the risk. Audiometric testing is recommended if these drugs are given concurrently. Patients should be advised to promptly notify their physician if they experience hearing loss or tinnitus.
References (6)
- Komune S, Snow JB (1981) "Potentiating effects of cisplatin and ethacrynic acid in ototoxicity." Arch Otolaryngol, 107, p. 594-7
- Rhodes T, Twentyman PR (1992) "A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines." Br J Cancer, 65, p. 684-90
- (2001) "Product Information. Edecrin (ethacrynic acid)." Merck & Co., Inc
- Brock PR, Knight KR, Freyer DR, et al. (2012) "Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of Pediatric Oncology Boston ototoxicity scale." J Clin Oncol, 30, p. 2408-17
- Parsons SK, Neault MW, Lehmann, et al. (1998) "Severe ototoxicity following carboplatin-containing conditioning regimen for autologous marrow transplantation for neuroblastoma." Bone Marrow Transplant, 22, p. 669-74
- Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O (2013) "Understanding platinum-induced ototoxicity." Trends Pharmacol Sci, 34, p. 458-69
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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