Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- cisplatin
- pegfilgrastim
Interactions between your drugs
CISplatin pegfilgrastim
Applies to: cisplatin, pegfilgrastim
ADJUST DOSING INTERVAL: The safety and efficacy of recombinant human granulocyte colony-stimulating factors (rhG-CSF) administered simultaneously with cytotoxic agents, including cancer chemotherapy, have not been established. Theoretical concerns exist regarding their concomitant administration because hematopoietic growth factors stimulate myeloid cell proliferation while antineoplastic agents primarily target rapidly dividing cells.
MANAGEMENT: The prescribing information for pegfilgrastim, eflapegrastim, and efbemalenograstim alfa recommends that these products not be administered between 14 days before and 24 hours after antineoplastic agents.
References (3)
- (2002) "Product Information. Neulasta (pegfilgrastim)." Amgen
- (2022) "Product Information. Rolvedon (eflapegrastim)." Spectrum Pharmaceuticals Inc, 2
- (2023) "Product Information. Ryzneuta Prefilled Syringe (efbemalenograstim alfa)." Evive Biotech
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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