Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Capastat Sulfate (capreomycin)
- rapacuronium
Interactions between your drugs
capreomycin rapacuronium
Applies to: Capastat Sulfate (capreomycin), rapacuronium
MONITOR: Like other polypeptide antibiotics, capreomycin may prolong apnea and respiratory paralysis after use of neuromuscular blocking agents. The mechanism may be related to decreased intracellular potassium or decreased ionized serum calcium. In some cases, intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B.
MANAGEMENT: Patients should be closely monitored for signs of excessive and/or extended neuromuscular blockade.
References (4)
- Kronenfeld MA, Thomas SJ, Turndorf H (1986) "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology, 65, p. 93-4
- Huang KC, Heise A, Shrader AK, Tsueda K (1990) "Vancomycin enhances the neuromuscular blockade of vecuronium." Anesth Analg, 71, p. 194-6
- (2001) "Product Information. Capastat Sulfate (capreomycin)." Dura Pharmaceuticals
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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