Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- fitusiran
- Oestrogel Pump-Pack (estradiol)
Interactions between your drugs
estradiol fitusiran
Applies to: Oestrogel Pump-Pack (estradiol), fitusiran
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Thrombotic events have been reported in fitusiran-treated patients, and concurrent use of hormonal contraceptives may increase the risk. Estrogen based hormonal contraceptives are an established risk factor for thrombosis in patients with inherited antithrombin (AT) deficiency.
MANAGEMENT: Concomitant use of fitusiran with estrogen based hormonal contraceptives should generally be avoided. Patients using hormonal contraceptives are advised to use alternative non-hormonal contraception prior to starting treatment with and while receiving fitusiran.
Drug and food interactions
estradiol food
Applies to: Oestrogel Pump-Pack (estradiol)
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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