Drug Interaction Report

Eluxadoline may increase the blood levels and effects of momelotinib. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as fever, chills, cough, chest pain, shortness of breath (with or without chest discomfort), diarrhea, dizziness, fatigue, pain, redness or swelling in an extremity, nausea or vomiting, unusual bruising or bleeding, dark urine, or pain on the right side of the abdomen. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Eluxadoline should be taken twice daily with food. You should avoid excessive alcohol use during treatment with eluxadoline. Consumption of more than 3 alcoholic beverages per day while taking eluxadoline may increase the risk of pancreatitis, or inflammation of the pancreas. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you experience potential symptoms of pancreatitis such as persistent nausea, vomiting, abdominal tenderness, and upper abdominal pain, especially that which is made worse after eating or radiates to the back or shoulders. Symptoms of pancreatitis usually go away when treatment with eluxadoline is stopped.