Drug Interaction Report

Patients that have been treated with palbociclib should let their doctor know before receiving allogeneic processed thymus tissue. Depending on the dose and length of time they have been on palbociclib, they may be at risk for reduced effects of allogeneic processed thymus tissue. Their doctor may already be aware of the risks, but has determined that this is the best course of treatment and has taken appropriate precautions and is monitoring closely for any potential complications. Patients should contact their doctor if their symptoms worsen or their condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Palbociclib oral capsules (Ibrance) should be taken with food to help with its absorption. Palbociclib oral tablets (Ibrance) may be taken with or without food. Do not consume grapefruit or grapefruit juice during treatment with palbociclib. Grapefruit and grapefruit juice can interact with palbociclib and increase the levels of palbociclib in your body. You may be more likely to experience side effects such as nausea; vomiting; diarrhea; loss of appetite; mouth sores; hair loss; weakness; pain, numbness, or tingling in the hands and feet; and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.