Drug Interaction Report

Mobocertinib may reduce the blood levels of levonorgestrel, which may make it less reliable as a form of birth control. Alternative methods of birth control should be used during treatment with mobocertinib and for 1 month after stopping treatment to avoid unintended pregnancy. This is particularly important because mobocertinib may cause fetal harm. Talk to your gynecologist or other healthcare professional for help in selecting an effective method of birth control that is best for you. Men with female partners of reproductive potential receiving mobocertinib should use a condom during the treatment period and for 1 week after stopping treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

You should avoid consumption of grapefruit and grapefruit juice during treatment with mobocertinib. Grapefruit juice can increase the blood levels of mobocertinib. This may increase the risk of side effects such as diarrhea, nausea, vomiting, rash, fatigue, musculoskeletal pain, mouth sores and inflammation, heart failure, and rare but potentially serious and life-threatening irregular heart rhythm disorders. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You may want to limit your consumption of grapefruit and grapefruit juice during treatment with levonorgestrel. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Contact your doctor if your condition changes or you experience increased side effects. Orange juice is not expected to interact.

Information for this minor interaction is available on the professional version.