Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- bretylium
- RectaGel HC (hydrocortisone / lidocaine topical)
Interactions between your drugs
bretylium lidocaine topical
Applies to: bretylium, RectaGel HC (hydrocortisone / lidocaine topical)
Coadministration of topical lidocaine with class III antiarrhythmics (e.g., amiodarone, dofetilide, sotalol) may lead to additive cardiovascular effects. Drug interaction studies evaluating class III antiarrhythmics with topical lidocaine formulations are unavailable. The degree of systemic absorption of topical lidocaine may be dependent on the duration of application and the applied surface area. Some authorities recommend increased clinical monitoring during concomitant use.
References (2)
- (2023) "Product Information. LMX 4 (lidocaine topical)." Ferndale Pharmaceuticals Ltd
- (2024) "Product Information. Xylocaine Topical (lidocaine topical)." Aspen Pharmacare Australia Pty Ltd
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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