Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- amifampridine
- Provocholine (methacholine)
Interactions between your drugs
methacholine amifampridine
Applies to: Provocholine (methacholine), amifampridine
MONITOR: Coadministration of amifampridine with direct or indirect cholinesterase inhibitors may result in additive cholinergic effects and increased adverse reactions such as nausea, diarrhea, abdominal pain, muscle weakness, dizziness, drowsiness, and seizures. Amifampridine may produce cholinergic effects by facilitating the release of acetylcholine from nerve endings and enhancing neuromuscular transmission.
MANAGEMENT: Patients should be apprised of the potential for increased cholinergic effects when amifampridine is coadministered with other drugs that have cholinergic effects such as cholinesterase inhibitors.
References (2)
- EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
- (2018) "Product Information. Firdapse (amifampridine)." Catalyst Pharmaceuticals, Inc.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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