Drug Interaction Report

Using benznidazole together with lactobacillus acidophilus may decrease the effects of lactobacillus acidophilus when these medications are taken at the same time. To prevent or minimize the interaction, lactobacillus acidophilus should be administered at least 1 to 2 hours before or after benznidazole. Contact your doctor if you have any concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Using benznidazole together with bifidobacterium infantis may decrease the effects of bifidobacterium infantis when these medications are taken at the same time. To prevent or minimize the interaction, bifidobacterium infantis should be administered at least 1 to 2 hours before or after benznidazole. Contact your doctor if you have any concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Consumption of alcoholic beverages or products containing alcohol or propylene glycol during treatment with benznidazole is not recommended. Doing so may occasionally trigger a reaction in some patients similar to the disulfiram reaction, which includes unpleasant effects such as flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion. Rarely, more severe reactions may include abnormal heart rhythm, heart attack, heart failure, unconsciousness, convulsions, and even death. Patients treated with benznidazole should continue to avoid using any products containing alcohol or propylene glycol for at least 3 days until after completion of therapy. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.