Drug Interaction Report

Benznidazole may affect the diagnostic results of sodium iodide I-131. Talk to your doctor before you are scheduled for testing to find out if and for how long you should stop using benznidazole so that it does not interfere with sodium iodide I-131 test results. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Consumption of alcoholic beverages or products containing alcohol or propylene glycol during treatment with benznidazole is not recommended. Doing so may occasionally trigger a reaction in some patients similar to the disulfiram reaction, which includes unpleasant effects such as flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion. Rarely, more severe reactions may include abnormal heart rhythm, heart attack, heart failure, unconsciousness, convulsions, and even death. Patients treated with benznidazole should continue to avoid using any products containing alcohol or propylene glycol for at least 3 days until after completion of therapy. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Iodine may interfere with the uptake of sodium iodide I-131 by the thyroid . A diet low in iodine and iodinated salt is recommended before starting therapy with sodium iodide I-131.

Multivitamin with minerals may affect the diagnostic results of sodium iodide I-131. Talk to your doctor before you are scheduled for testing to find out if and for how long you should stop using multivitamin with minerals so that it does not interfere with sodium iodide I-131 test results. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.