Drug Interaction Report

MONITOR CLOSELY: Aminoglycosides possess neuromuscular blocking activity, which may be additive with that of parenteral magnesium, potentially resulting in severe and/or prolonged respiratory depression during concomitant use. Clinical data are limited; however, this interaction has been reported in animal studies. In addition, aminoglycosides may reduce serum magnesium levels.

MANAGEMENT: Close monitoring for increased or prolonged neuromuscular blockade and respiratory depression is recommended during concomitant use, especially in patients with renal impairment and/or with elevated magnesium levels. It may be advisable to avoid administration of aminoglycosides in infants with hypermagnesemia.