Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- fidaxomicin
- Provella (bifidobacterium infantis / lactobacillus acidophilus)
Interactions between your drugs
lactobacillus acidophilus fidaxomicin
Applies to: Provella (bifidobacterium infantis / lactobacillus acidophilus), fidaxomicin
ADJUST DOSING INTERVAL: Coadministration of oral probiotic preparations with oral antibiotics may reduce the efficacy of the probiotic. It has been theorized that concomitant antibiotics may kill the live organisms found in lactobacillus-, bacillus coagulans-, and bifidobacteria-containing oral probiotic preparations. However, the clinical significance of the interaction has not been established.
MANAGEMENT: Although data are limited, it may be prudent to advise patients to take oral probiotics at least 1 to 2 hours before or after an oral antibiotic.
References (3)
- Clarion Brands, Inc. (2020) Florajen Probiotics. https://www.florajen.com/products/florajen-women
- Xiao JZ, Takahashi S, Odamaki T, Yaeshima T, iwatsuki k (2010) "Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market." Biosci Biotechnol Biochem, 74, p. 336-42
- dwyer a (2024) Taking probiotics with antibiotics https://www.optibacprobiotics.com/learning-lab/in-depth/general-health/probiotics-with-antibiotics
bifidobacterium infantis fidaxomicin
Applies to: Provella (bifidobacterium infantis / lactobacillus acidophilus), fidaxomicin
ADJUST DOSING INTERVAL: Coadministration of oral probiotic preparations with oral antibiotics may reduce the efficacy of the probiotic. It has been theorized that concomitant antibiotics may kill the live organisms found in lactobacillus-, bacillus coagulans-, and bifidobacteria-containing oral probiotic preparations. However, the clinical significance of the interaction has not been established.
MANAGEMENT: Although data are limited, it may be prudent to advise patients to take oral probiotics at least 1 to 2 hours before or after an oral antibiotic.
References (3)
- Clarion Brands, Inc. (2020) Florajen Probiotics. https://www.florajen.com/products/florajen-women
- Xiao JZ, Takahashi S, Odamaki T, Yaeshima T, iwatsuki k (2010) "Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market." Biosci Biotechnol Biochem, 74, p. 336-42
- dwyer a (2024) Taking probiotics with antibiotics https://www.optibacprobiotics.com/learning-lab/in-depth/general-health/probiotics-with-antibiotics
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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