Drug Interaction Report

Canakinumab may decrease the blood levels and effects of sildenafil. You may need a dose adjustment if you have been receiving sildenafil and are starting treatment with canakinumab. Likewise, if you have been receiving both medications, the dose of sildenafil may need to be adjusted when canakinumab is discontinued. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

If you are receiving therapy with sildenafil you should avoid the regular consumption of large amounts of grapefruits and grapefruit juice. Grapefruit can raise the levels of sildenafil in your body and delay the time it takes for the medication to work. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.