Drug Interaction Report

Talk to your doctor before using vitamin E together with estramustine. Regular use of antioxidant supplements including vitamin E may reduce the effectiveness of estramustine and other cancer treatments including radiation therapy. In addition, taking excessive amounts of vitamin E may cause harm to your heart. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food and milk may decrease the levels of estramustine in your body. It is recommended that estramustine be taken at least 1 hour before or 2 hours after meals. This will make it easier for your body to absorb the medication. Estramustine should not be taken with milk or calcium containing products.