Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- topotecan
- vimseltinib
Interactions between your drugs
topotecan vimseltinib
Applies to: topotecan, vimseltinib
GENERALLY AVOID: Coadministration with vimseltinib may increase the plasma concentrations of drugs that are substrates of the breast cancer resistance protein (BCRP) efflux transporter. The proposed mechanism, based on in vitro data, is decreased clearance due to inhibition of BCRP-mediated intestinal and/or hepatic transport by vimseltinib. Clinical data are not available.
MANAGEMENT: Concomitant use of vimseltinib with BCRP substrates should generally be avoided. If coadministration is considered necessary, the individual product labeling of the BCRP substrate should be consulted for specific guidance.
References (1)
- (2025) "Product Information. Romvimza (vimseltinib)." Deciphera Pharmaceuticals
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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