Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- tizanidine
- viloxazine
Interactions between your drugs
tiZANidine viloxazine
Applies to: tizanidine, viloxazine
CONTRAINDICATED: Coadministration of viloxazine, a potent inhibitor of CYP450 1A2, may significantly increase the risk of adverse reactions to sensitive CYP450 1A2 substrates or CYP450 1A2 substrates with a narrow therapeutic range. According to the prescribing information, viloxazine increased the systemic exposure (AUC) of caffeine, a probe CYP450 1A2 substrate, by nearly 6-fold without affecting its peak plasma concentration (Cmax).
MANAGEMENT: Concomitant use of viloxazine with sensitive CYP450 1A2 substrates or CYP450 1A2 substrates with a narrow therapeutic range such as alosetron, duloxetine, ramelteon, tasimelteon, tizanidine, or theophylline is contraindicated.
References (1)
- (2021) "Product Information. Qelbree (viloxazine)." Supernus Pharmaceuticals Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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