Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Profenal (suprofen ophthalmic)
- rucaparib
Interactions between your drugs
suprofen ophthalmic rucaparib
Applies to: Profenal (suprofen ophthalmic), rucaparib
MONITOR: Coadministration with rucaparib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of CYP450 2C9. The proposed mechanism is decreased clearance due to rucaparib-mediated inhibition of CYP450 2C9. In a clinical study, rucaparib increased S-warfarin Cmax and AUC by 1.05- and 1.49-fold, respectively.
MANAGEMENT: Caution is advised if rucaparib is used concomitantly with drugs that are substrates of CYP450 2C9, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever rucaparib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.
References (1)
- EMA. European Medicines Agency. European Union (2013) EMA - List of medicines under additional monitoring. http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Ocufen
Ocufen is used for inhibition of intraoperative miosis, postoperative ocular inflammation
Acular
Acular is used for corneal refractive surgery, postoperative ocular inflammation, seasonal allergic ...
Taltz
Taltz (ixekizumab) is used to treat plaque psoriasis, psoriatic arthritis, and ankylosing ...
Acular LS
Acular LS is used for corneal refractive surgery, postoperative ocular inflammation, seasonal ...
Acular PF
Acular PF is used for corneal refractive surgery, postoperative ocular inflammation, seasonal ...
Acuvail
Acuvail is used to treat pain and inflammation following cataract surgery. Learn about side ...
Miebo
Miebo (perfluorohexyloctane) is used to treat the signs and symptoms of dry eye disease. Includes ...
Nevanac
Nevanac (nepafenac ophthalmic) is used to reduce pain and swelling after cataract surgery. Includes ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.