Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- oxandrolone
- torsemide
Interactions between your drugs
oxandrolone torsemide
Applies to: oxandrolone, torsemide
MONITOR: Coadministration with inhibitors of CYP450 2C9 may increase the plasma concentrations of torsemide. The interaction has not been evaluated in pharmacokinetic studies; however, torsemide has been shown to undergo metabolism by CYP450 2C9.
MANAGEMENT: Caution is advised when torsemide is prescribed with CYP450 2C9 inhibitors. Patients should be monitored for potentially increased adverse effects such as dehydration, hypotension, electrolyte imbalances, hyperglycemia, tinnitus, and hearing loss.
References (4)
- "Product Information. Demadex (torsemide)." Boehringer Mannheim
- Miners JO, Rees DLP, Valente L, Veronese ME, Birkett DJ (1995) "Human hepatic cytochrome p450 2c9 catalyzes the rate-limiting pathway of torsemide metabolism." J Pharmacol Exp Ther, 272, p. 1076-81
- Miners JO, Birkett DJ (1998) "Cytochrome P4502C9: an enzyme of major importance in human drug metabolism." Br J Clin Pharmacol, 45, p. 525-38
- Vormfelde SV, Engelhardt S, Zirk A, et al. (2004) "CYP2C9 polymorphisms and the interindividual variability in pharmacokinetics and pharmacodynamics of the loop diuretic drug torsemide." Clin Pharmacol Ther, 76, p. 557-66
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Genotropin
Genotropin is a human growth hormone used to treat growth failure in children and adults who lack ...
Marinol
Marinol is a man-made form of cannabis used to treat loss of appetite in people with AIDS. Learn ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Norditropin
Norditropin is used to treat growth hormone deficiency (GHD) in adults and children and other ...
Omnitrope
Omnitrope (somatropin) is a form of human growth hormone used to treat adults and children with ...
Humatrope
Humatrope injection (somatropin) is a human growth hormone used to treat growth failure in children ...
Norditropin FlexPro
Norditropin FlexPro is used for adult human growth hormone deficiency, idiopathic short stature ...
Zomacton
Zomacton is used for adult human growth hormone deficiency, idiopathic short stature, pediatric ...
Nutropin AQ
Nutropin AQ (somatropin) is an injectable preparation that may be used to treat children with ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.