Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- milk thistle
- Olysio (simeprevir)
Interactions between your drugs
milk thistle simeprevir
Applies to: milk thistle, Olysio (simeprevir)
GENERALLY AVOID: Coadministration with milk thistle may increase the plasma concentrations of simeprevir. The proposed mechanism is inhibition of CYP450 3A4-mediated metabolism by milk thistle.
MANAGEMENT: The use of simeprevir with products containing milk thistle should generally be avoided.
References (1)
- (2013) "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals
Drug and food/lifestyle interactions
simeprevir food/lifestyle
Applies to: Olysio (simeprevir)
ADJUST DOSING INTERVAL: Food significantly enhances the oral bioavailability of simeprevir, although the type of food does not seem to matter. In healthy study subjects, administration of simeprevir after a high-fat, high-caloric (928 kcal) breakfast increased systemic exposure (AUC) by 61% and delayed absorption by 1 hour, while administration after a normal caloric (533 kcal) breakfast increased AUC by 69% and delayed absorption by 1.5 hours.
MANAGEMENT: To ensure maximal oral absorption, simeprevir should be administered with food.
References (1)
- (2013) "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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