Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- methenamine / sodium acid phosphate
- mexiletine
Interactions between your drugs
mexiletine sodium acid phosphate (obsolete)
Applies to: mexiletine, methenamine / sodium acid phosphate
Agents that acidify the urine enhance the plasma clearance of mexiletine. The result may be decreased plasma mexiletine levels and decreased effectiveness. The clinical significance is unknown. It is recommended that such drugs or diet be discontinued or that mexiletine dosage increased as needed and tolerated.
References (1)
- Mitchell BG, Clements JA, Pottage A, Prescott LF (1983) "Mexiletine disposition: individual variation in response to urine acidification and alkalinisation." Br J Clin Pharmacol, 16, p. 281-4
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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