Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- ambenonium
- Quelicin (succinylcholine)
Interactions between your drugs
succinylcholine ambenonium
Applies to: Quelicin (succinylcholine), ambenonium
MONITOR: Acetylcholinesterase inhibitors may prolong and/or enhance the muscle relaxation effects of succinylcholine by blocking the activity of plasma cholinesterase, the enzyme responsible for the hydrolysis of succinylcholine. Prolonged neuromuscular blockade and respiratory depression may occur.
MANAGEMENT: It may be appropriate to discontinue acetylcholinesterase inhibitor therapy for a few days before the procedure depending on the needs of the patient. Otherwise, the patient should be monitored closely for increased pharmacologic effects of succinylcholine. Peripheral nerve stimulators are recommended for accurate assessment of neuromuscular blockade in patients who have been taking pyridostigmine.
References (6)
- Freeman SE, Dawson RM (1991) "Tacrine: a pharmacological review." Prog Neurobiol, 36, p. 257-77
- (2001) "Product Information. Aricept (donepezil)." Pfizer U.S. Pharmaceuticals
- (2001) "Product Information. Reminyl (galantamine)." Janssen Pharmaceuticals
- Keeler JR (1990) "Interactions between nerve agent pretreatment and drugs commonly used in combat anesthesia." Mil Med, 155, p. 527-33
- Heath ML (2003) "Donepezil and succinylcholine." Anaesthesia, 58, p. 202
- (2024) "Product Information. Zunveyl (benzgalantamine)." Alpha Cognition, Inc., SUPPL-1
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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