Drug Interaction Report

Using mavorixafor with IDArubicin may require additional monitoring. Mavorixafor is an inhibitor of pathways the body uses to process IDArubicin. In most cases this pathway is used to eliminate the medication, so blocking this pathway could lead to a significant increase in side effects. In some cases, this pathway is used to activate the medication, so blocking this pathway could make such medications less effective in treating your condition. Additionally, using mavorixafor together with IDArubicin may increase the risk of experiencing a change in the electrical activity of your heart called QT prolongation, which can result in irregular heartbeats that can be life-threatening. You might be more susceptible to this risk if you have heart problems, congenital long QT syndrome, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). You may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you experience an irregular heartbeat or feel dizzy, lightheaded, or faint during treatment. Speak with your doctor or healthcare provider if you have any questions. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Mavorixafor should be taken on an empty stomach after an overnight fast, 30 minutes before food. Do not consume grapefruit products during treatment with mavorixafor unless otherwise directed by your doctor. Grapefruit juice can increase the blood levels and adverse effects of mavorixafor, increasing the risk of experiencing a change in the electrical activity of your heart called QT prolongation, which can result in irregular heartbeats that can be life-threatening. You should seek immediate medical attention if you experience an irregular heartbeat or feel dizzy, lightheaded, or faint during treatment. Speak with your doctor or healthcare provider if you have any questions. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.