Drug Interaction Report
This report displays the potential drug interactions for the following 2 drugs:
- histamine phosphate
- Pediatex (carbinoxamine)
Interactions between your drugs
carbinoxamine histamine phosphate
Applies to: Pediatex (carbinoxamine), histamine phosphate
MONITOR: Antihistamines may suppress the patient's response to histamine phosphate. The length of suppression varies and is dependent on the patient, type of antihistamine, and the duration of antihistamine therapy. The duration of suppression may range from 24 hours with chlorpheniramine or up to several weeks with second-generation antihistamines.
MANAGEMENT: Clinicians should be aware of the potential for falsely insignificant or false-negative results when administering histamine phosphate to patients treated with antihistamines.
- "Product Information. Histatrol (histamine phosphate)." Center Laboratories, Port Washington, NY.
Drug and food interactions
Applies to: Pediatex (carbinoxamine)
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
- Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7
- "Product Information. Fycompa (perampanel)." Eisai Inc, Teaneck, NJ.
- "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc, Rockville, MD.
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.