Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- fluconazole
- terbinafine
Interactions between your drugs
fluconazole terbinafine
Applies to: fluconazole, terbinafine
MONITOR: Inhibitors of CYP450 2C9 and 3A4 may increase the systemic exposure to terbinafine. In a clinical study, coadministration of single doses of fluconazole 100 mg and terbinafine 750 mg increased the maximum plasma concentration and AUC of terbinafine by 52% and 69%, respectively. Although clinical data are lacking, amiodarone and ketoconazole may also significantly increase the systemic exposure to terbinafine.
MANAGEMENT: It is advisable to monitor patients for side effects during coadministration, such as diarrhea, abdominal pain, liver function test abnormalities, rashes, urticaria, and pruritus.
References (4)
- (2001) "Product Information. Diflucan (fluconazole)." Roerig Division
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Cerner Multum, Inc. "Australian Product Information."
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Antifungal agents
Therapeutic duplication
The recommended maximum number of medicines in the 'antifungal agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antifungal agents' category:
- fluconazole
- terbinafine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Diflucan
Diflucan (fluconazole) is used to treat and prevent fungal infections. Includes Diflucan side ...
Sporanox
Sporanox (itraconazole) is used to treat fungal infections of the lungs, mouth, throat, toenails ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Fungizone
Fungizone is used for aspergillosis, aspergilloma, aspergillosis, invasive, blastomycosis, candida ...
Tolsura
Tolsura is used for aspergillosis, invasive, blastomycosis, histoplasmosis
Leukine
Leukine increases white blood cells and decreases the risk of infection in conditions such as ...
Sargramostim
Sargramostim is used for aplastic anemia, bone marrow transplantation, bone marrow transplantation ...
Flucytosine
Flucytosine is used for candida urinary tract infection, candidemia, cryptococcal meningitis ...
Amphotericin b
Amphotericin b is used for aspergillosis, aspergilloma, aspergillosis, invasive, blastomycosis ...
Itraconazole
Itraconazole is used for aspergillosis, aspergilloma, aspergillosis, invasive, blastomycosis ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.