Diethyl Phthalate
Medically reviewed by Drugs.com. Last updated on May 19, 2021.
Excipient (pharmacologically inactive substance)
What is it?
Diethyl phthalate (C12H14O4), or DEP is a diethyl ester of phthalic acid. DEP is used as a plasticizer in consumer goods, including plastic packaging films, cosmetics, solvent for fragrances, a surface lubricant in food and pharmaceutical packaging, and in tubing used for medical purposes. It is a colorless, oily liquid.[1]
There are concerns about the toxicity of phthalates in consumer products and the environment. Exposure to DEP can occur through inhalation, ingestion, eye or skin contact. Some studies suggest little toxicity, but other research has identified reproductive toxicity in animal studies.[2]
According to a document published by the Centers for Disease Control and Prevention (CDC) for occupational safety, diethyl phthalate has irritant effects on the eyes, skin, and mucous membranes and can lead to central nervous system (CNS) effects in exposed workers. CNS effects only occurred in exposed workers after 6 to 7 years of chronic exposure to phthalates.[3]
Top Medications with this Excipient
- Carbamazepine 200 mg
- Didanosine Delayed Release 125 mg
- Didanosine Delayed Release 200 mg
- Didanosine Delayed Release 250 mg
- Diltiazem Hydrochloride Extended-Release (SR) 90 mg
- Galantamine Hydrobromide Extended Release 16 mg
- Galantamine Hydrobromide Extended Release 24 mg
- Kadian 150 mg
- Kadian 70 mg
- Lamotrigine Extended-Release 50 mg
- Lamotrigine Extended-Release 25 mg
- Morphine Sulfate Extended Release 50 mg
- Morphine Sulfate Extended Release 100 mg
- Morphine Sulfate Extended-Release 30 mg
- Morphine Sulfate Extended-Release 30 mg
- Morphine Sulfate Extended-Release 20 mg
- Propranolol Hydrochloride Extended-Release 60 mg
- Ranitidine Hydrochloride 150 mg
- Ropinirole Hydrochloride Extended-Release 8mg
- Ropinirole Hydrochloride Extended-Release 12 mg
References
[1] Chemical Information Profile for Diethyl Phthalate. National Toxicology Program National Institute of Environmental Health Sciences National Institutes of Health U.S. Department of Health and Human Services Research Triangle Park, NCNIH. http://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/diethyl_phthalate.pdf
[2] Autian J. Toxicity and health threats of phthalate esters: review of the literature. Environmental Health Perspectives 1973. 4: 3–25. Accessed March 31, 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474854/pdf/envhper00501-0008.pdf
[3] CDC. Occupational Health and Safety Guideline for Diethyl Phthalate. http://www.cdc.gov/niosh/docs/81-123/pdfs/0213.pdf
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.