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Aptivus and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Aptivus (tipranavir).

Moderate

Tipranavir Food

Moderate Food Interaction

Tipranavir should be taken with food. This helps to reduce the gastrointestinal side effects of ritonavir, which you must also take with tipranavir in order to achieve effective blood levels of the medication against HIV. Talk to your doctor or pharmacist if you have any questions on how to use these medications properly.

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Moderate

Tipranavir High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

PIs - hyperlipidemia

Treatment with ritonavir alone or in combination with other protease inhibitors (e.g., lopinavir, saquinavir, tipranavir, fosamprenavir) has resulted in substantial increases in the concentration of total cholesterol and triglycerides. These effects have also been reported with other protease inhibitors but may be the most dramatic with ritonavir. The clinical significance of these elevations is unclear. Marked elevation in triglyceride levels is a risk factor for development of pancreatitis. Triglyceride and cholesterol testing is recommended before starting ritonavir (with or without other protease inhibitors) and periodically during therapy. Lipid disorders should be managed as clinically appropriate.

References

  1. (2022) "Product Information. Norvir (ritonavir)." AbbVie US LLC, SUPPL-25
  2. (2020) "Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb, SUPPL-44
  3. (2019) "Product Information. Lexiva (fosamprenavir)." ViiV Healthcare, SUPPL-41
  4. (2020) "Product Information. Kaletra (lopinavir-ritonavir)." AbbVie US LLC, SUPPL-54
  5. (2020) "Product Information. Invirase (saquinavir)." Roche Laboratories, SUPPL-25
  6. (2020) "Product Information. Aptivus (tipranavir)." Boehringer Ingelheim, SUPPL-21
View all 6 references

Aptivus drug interactions

There are 360 drug interactions with Aptivus (tipranavir).

Aptivus disease interactions

There are 4 disease interactions with Aptivus (tipranavir) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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