Aptivus (tipranavir) and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with Aptivus (tipranavir) which include:
tipranavir ↔ food
Moderate Food Interaction
Tipranavir should be taken with food. This helps to reduce the gastrointestinal side effects of ritonavir, which you must also take with tipranavir in order to achieve effective blood levels of the medication against HIV. Talk to your doctor or pharmacist if you have any questions on how to use these medications properly.
High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, High plausibility
PIs - hyperlipidemia
Hyperlipidemia has been observed in 10% of patients receiving ritonavir during clinical trials. Increases of 30% to 40% from baseline have been reported for total cholesterol and 200% to 300% or more for triglycerides. These effects have also been reported during postmarketing experience with other protease inhibitors (PIs) but may be the most dramatic with ritonavir. The clinical significance of these elevations is unclear. Severe hyperlipidemia is known to sometimes cause pancreatitis. In addition, some patients have reportedly developed symptomatic atherosclerosis and coronary artery disease after initiating PI treatment. Patients with preexisting hyperlipidemia may require closer monitoring during PI therapy, and adjustments made accordingly in their lipid-lowering regimen. PI therapy should be administered cautiously in patients with coronary artery disease or a history of ischemic heart disease.
- "Product Information. Lexiva (fosamprenavir)." GlaxoSmithKline, Research Triangle Park, NC.
- "Product Information. Agenerase (amprenavir)." Glaxo Wellcome, Research Triangle Pk, NC.
- "Product Information. Invirase (saquinavir)." Roche Laboratories, Nutley, NJ.
Aptivus (tipranavir) drug Interactions
There are 436 drug interactions with Aptivus (tipranavir)
Aptivus (tipranavir) disease Interactions
There are 4 disease interactions with Aptivus (tipranavir) which include:
Drug Interaction Classification
Do not stop taking any medications without consulting your healthcare provider.