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Prograf and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Prograf (tacrolimus).


Tacrolimus Food

Moderate Food Interaction

Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each day. Grapefruit and grapefruit juice may increase the amount of tacrolimus in your body. This can lead to potentially dangerous side effects and should be avoided. If you are already consuming grapefruit products, do not increase or decrease the amount of these products in your diet without first talking to your doctor.

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Tacrolimus High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

tacrolimus - hypertension

The use of tacrolimus has been associated with hypertension. Therapy with tacrolimus should be administered cautiously in patients with elevated blood pressure. Close monitoring of blood pressure is recommended.


  1. (2001) "Product Information. Prograf (tacrolimus)." Fujisawa

Prograf drug interactions

There are 835 drug interactions with Prograf (tacrolimus).

Prograf disease interactions

There are 7 disease interactions with Prograf (tacrolimus) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.