Sotorasib and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with sotorasib.
Sotorasib Food/Lifestyle
Minor Food Interaction
Food does not appear to have a clinically significant effect on the oral bioavailability of sotorasib. When a 960 mg dose of sotorasib was administered to study patients with a high-fat, high-calorie meal (approximately 800 to 1000 calories; 150, 250, and 500 to 600 calories from protein, carbohydrate, and fat, respectively), sotorasib peak plasma concentration (Cmax) did not change while systemic exposure (AUC 0-24 hours) increased by 25% compared to administration under fasted conditions. Sotorasib can be administered with or without food at approximately the same time each day.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2021) "Product Information. Lumakras (sotorasib)." Amgen USA
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Sotorasib drug interactions
There are 509 drug interactions with sotorasib.
Sotorasib disease interactions
There is 1 disease interaction with sotorasib which include:
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- During pregnancy
- Drug class: miscellaneous antineoplastics
- Breastfeeding
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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