Sirolimus and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with sirolimus.
Sirolimus Food/Lifestyle
Moderate Food Interaction
ADJUST DOSING INTERVAL: Consumption of food can decrease the rate and extent of gastrointestinal absorption of sirolimus. Also, the consumption of grapefruit juice may result in increased sirolimus trough concentrations.
MANAGEMENT: Experts recommend that this drug be taken either at least one hour prior to eating or consistently with or without food to avoid variations in sirolimus blood levels. The manufacturer recommends against using grapefruit juice for dilution of sirolimus doses. Patients should be monitored for clinical and laboratory evidence of altered immunosuppressant effects.
References (1)
- (2001) "Product Information. Rapamune (sirolimus)." Wyeth-Ayerst Laboratories
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Sirolimus High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
sirolimus - hyperlipidemia
The use of sirolimus may increase serum cholesterol and triglycerides. Care should be taken when prescribing this agent to hyperlipidemic patients. It is recommended to assess the risk/benefit carefully when considering this agent in patients with established hyperlipidemia before initiating therapy. It is recommended to monitor patients regularly for elevated lipids.
References (1)
- (2001) "Product Information. Rapamune (sirolimus)." Wyeth-Ayerst Laboratories
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Sirolimus drug interactions
There are 726 drug interactions with sirolimus.
Sirolimus disease interactions
There are 9 disease interactions with sirolimus which include:
- infections
- PML
- angioedema
- hyperlipidemia
- liver disease
- liver transplantation
- lung dysfunction
- lung transplant
- renal dysfunction
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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