Sirolimus and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with sirolimus.
Sirolimus Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Consumption of food can decrease the rate and extent of gastrointestinal absorption of sirolimus. Also, the consumption of grapefruit juice may result in increased sirolimus trough concentrations.
MANAGEMENT: Experts recommend that this drug be taken either at least one hour prior to eating or consistently with or without food to avoid variations in sirolimus blood levels. The manufacturer recommends against using grapefruit juice for dilution of sirolimus doses. Patients should be monitored for clinical and laboratory evidence of altered immunosuppressant effects.
References (1)
- (2001) "Product Information. Rapamune (sirolimus)." Wyeth-Ayerst Laboratories
Switch to consumer interaction data
Sirolimus High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
sirolimus - hyperlipidemia
The use of sirolimus may increase serum cholesterol and triglycerides. Care should be taken when prescribing this agent to hyperlipidemic patients. It is recommended to assess the risk/benefit carefully when considering this agent in patients with established hyperlipidemia before initiating therapy. It is recommended to monitor patients regularly for elevated lipids.
References (1)
- (2001) "Product Information. Rapamune (sirolimus)." Wyeth-Ayerst Laboratories
Switch to consumer interaction data
Sirolimus drug interactions
There are 718 drug interactions with sirolimus.
Sirolimus disease interactions
There are 9 disease interactions with sirolimus which include:
- infections
- PML
- angioedema
- hyperlipidemia
- liver disease
- liver transplantation
- lung dysfunction
- lung transplant
- renal dysfunction
Report options
More about sirolimus
- sirolimus consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (8)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: mTOR inhibitors
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
CellCept
Cellcept (mycophenolate mofetil) is used to prevent rejection of a kidney, liver, or heart ...
Imuran
Imuran is used for atopic dermatitis, autoimmune hepatitis, chronic active hepatitis, chronic ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Prograf
Prograf is used to prevent your body from rejecting a heart, liver, or kidney transplant. Learn ...
Cytoxan
Cytoxan is used for acute lymphocytic leukemia, acute nonlymphocytic leukemia, breast cancer ...
Rapamune
Rapamune (sirolimus) is used to prevent rejection in people who have received a kidney transplant ...
Afinitor
Afinitor prevents the growth of cancer cells and is used to treat advanced kidney cancer. Learn ...
Everolimus
Everolimus (Afinitor, Afinitor Disperz, Zortress) belongs to a class of drugs called kinase ...
Cyclophosphamide
Cyclophosphamide systemic is used for acute lymphocytic leukemia, acute nonlymphocytic leukemia ...
Cyclosporine
Cyclosporine systemic is used for cogan's syndrome, crohn's disease, eczema, evan's syndrome, focal ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
