Rapamune and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Rapamune (sirolimus).
Moderate Food Interaction
Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. Also, you should preferably take sirolimus at least one hour before eating. If you do take it with food, you should take it each time with food to avoid changes in sirolimus levels. The oral liquid form of sirolimus must be mixed with water or orange juice only. Do not use grapefruit juice to mix this medication.
High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
sirolimus - hyperlipidemia
The use of sirolimus may increase serum cholesterol and triglycerides. Care should be taken when prescribing this agent to hyperlipidemic patients. It is recommended to assess the risk/benefit carefully when considering this agent in patients with established hyperlipidemia before initiating therapy. It is recommended to monitor patients regularly for elevated lipids.
- "Product Information. Rapamune (sirolimus)." Wyeth-Ayerst Laboratories (2001):
Rapamune drug interactions
There are 634 drug interactions with Rapamune (sirolimus).
Rapamune disease interactions
There are 9 disease interactions with Rapamune (sirolimus) which include:
- liver disease
- liver transplantation
- lung dysfunction
- lung transplant
- renal dysfunction
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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