Odevixibat and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with odevixibat.
Multivitamins With Minerals Odevixibat
Moderate Drug Interaction
MONITOR: Odevixibat may affect absorption of fat-soluble vitamins (FSV) including vitamin A, D, E, and K. In clinical studies, new onset or worsening of existing FSV deficiency was reported in 5% of placebo-treated patients, and in 16% of odevixibat-treated 120 mcg/kg/day patients. However, none of the odevixibat-treated 40 mcg/kg/day patients had new onset or worsening of existing FSV deficiency.
MANAGEMENT: Clinical and laboratory monitoring of FSV levels is recommended at baseline and during treatment with odevixibat. If FSV deficiency is diagnosed, supplement with FSV. Odevixibat should be discontinued if FSV deficiency persists or worsens despite adequate FSV supplementation.
References (1)
- (2021) "Product Information. Bylvay (odevixibat)." Albireo Pharma, Inc.
Odevixibat Food/Lifestyle
Moderate Food Interaction
MONITOR: Odevixibat may affect absorption of fat-soluble vitamins (FSV) including vitamin A, D, E, and K. In clinical studies, new onset or worsening of existing FSV deficiency was reported in 5% of placebo-treated patients, and in 16% of odevixibat-treated 120 mcg/kg/day patients. However, none of the odevixibat-treated 40 mcg/kg/day patients had new onset or worsening of existing FSV deficiency.
MANAGEMENT: Clinical and laboratory monitoring of FSV levels is recommended at baseline and during treatment with odevixibat. If FSV deficiency is diagnosed, supplement with FSV. Odevixibat should be discontinued if FSV deficiency persists or worsens despite adequate FSV supplementation.
References (1)
- (2021) "Product Information. Bylvay (odevixibat)." Albireo Pharma, Inc.
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Odevixibat drug interactions
There are 28 drug interactions with odevixibat.
Odevixibat disease interactions
There are 3 disease interactions with odevixibat which include:
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- Drug class: miscellaneous GI agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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