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Odevixibat Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 18, 2022.

Applies to odevixibat: oral capsule, oral pellet.

Serious side effects of Odevixibat

Along with its needed effects, odevixibat may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking odevixibat:

More common

  • Clay-colored stools
  • confusion
  • dark urine
  • decreased urination
  • diarrhea
  • dizziness
  • dry mouth
  • fainting
  • fever
  • headache
  • increased heart rate
  • lightheadedness
  • loss of appetite
  • nausea
  • rapid breathing
  • skin rash
  • stomach pain, fullness, or tenderness
  • sunken eyes
  • swelling of the feet or lower legs
  • thirst
  • unusual tiredness or weakness
  • vomiting
  • wrinkled skin
  • yellow eyes or skin

Less common

  • Fracture

For Healthcare Professionals

Applies to odevixibat: oral capsule, oral pellet.

General

The most commonly reported side effects included diarrhea, increased transaminases, vomiting, and abdominal pain.[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 39.1%), vomiting (up to 17.4%), abdominal pain (up to 15.8%)[Ref]

Hepatic

Very common (10% or more): Increased transaminases (ALT, AST) (up to 21.1%), increased blood bilirubin (up to 13%)

Common (1% to 10%): Cholelithiasis[Ref]

Metabolic

Very common (10% or more): Fat-soluble vitamin deficiency (vitamin A, D, E) (up to 15.8%)

Common (1% to 10%): Dehydration[Ref]

Hematologic

Very common (10% or more): Splenomegaly (up to 10.5%)[Ref]

Musculoskeletal

Common (1% to 10%): Fracture[Ref]

References

1. "Product Information. Bylvay (odevixibat)." Albireo Pharma, Inc. (2021):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.