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Fomepizole and Alcohol/Food Interactions

There is 1 alcohol/food/lifestyle interaction with fomepizole.

Major

Alcohol (Ethanol) fomepizole

Major Drug Interaction

GENERALLY AVOID: The manufacturer reports that oral doses of fomepizole (10 to 20 mg/kg) will significantly reduce the rate of elimination of moderate doses of ethanol by approximately 40% when given to healthy volunteers. The mechanism is via alcohol dehydrogenase inhibition. By a similar mechanism, ethanol will decrease the rate of elimination of fomepizole.

MANAGEMENT: In general, ethanol and fomepizole should not be coadministered in the treatment of ethylene glycol poisoning.

References

  1. (2001) "Product Information. Antizol (fomepizole)." Jazz Pharmaceuticals

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Fomepizole drug interactions

There is 1 drug interaction with fomepizole.

Fomepizole disease interactions

There is 1 disease interaction with fomepizole which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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