Fomepizole Disease Interactions
There is 1 disease interaction with fomepizole.
Fomepizole (applies to fomepizole) hepatic/renal dysfunction
Moderate Potential Hazard, Low plausibility. Applicable conditions: Liver Disease
The pharmacokinetic disposition of fomepizole has not been determined in patients with hepatic and/or renal impairment. Fomepizole is extensively metabolized by the liver. Following multiple dosing, fomepizole induces its own metabolism and the rate of elimination is increased. About 1% to 3.5% of fomepizole is eliminated unchanged in the urine. Therapy with fomepizole should be administered cautiously in patients with compromised hepatic and/or renal function. Fomepizole is dialyzable and the frequency of dosing should be increased to every 4 hours during hemodialysis.
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Fomepizole drug interactions
There is 1 drug interaction with fomepizole.
Fomepizole alcohol/food interactions
There is 1 alcohol/food interaction with fomepizole.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.