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Dextrothyroxine sodium and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with dextrothyroxine sodium which include:

Major

High Blood Pressure (Hypertension)

Severe Potential Hazard, High plausibility

dextrothyroxine - cardiovascular disease

The use of dextrothyroxine sodium is contraindicated in euthyroid patients with one or more of the following conditions: hypertension (other than mild, labile systolic hypertension); known or suspected organic heart disease, especially coronary heart disease; a history of myocardial infarction; cardiac arrhythmias or a demonstrated propensity for arrhythmias; tachycardia; rheumatic heart disease; a history of congestive heart failure; or decompensated or borderline compensated cardiac status. Dextrothyroxine sodium may cause severe cardiotoxicity related to its thyroid hormone activity, occasionally even in patients without apparent underlying cardiac abnormalities. In a large study involving men who had had a myocardial infarction, treatment with dextrothyroxine sodium was associated with a trend toward increased mortality relative to placebo. Therapy with dextrothyroxine sodium should be considered and administered cautiously in patients with risk factors for coronary artery disease, including obesity, a history of smoking, and/or a family history of premature coronary disease.

References

  1. "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company, Mount Olive, NJ.
Major

Obesity

Severe Potential Hazard, High plausibility

dextrothyroxine - cardiovascular disease

The use of dextrothyroxine sodium is contraindicated in euthyroid patients with one or more of the following conditions: hypertension (other than mild, labile systolic hypertension); known or suspected organic heart disease, especially coronary heart disease; a history of myocardial infarction; cardiac arrhythmias or a demonstrated propensity for arrhythmias; tachycardia; rheumatic heart disease; a history of congestive heart failure; or decompensated or borderline compensated cardiac status. Dextrothyroxine sodium may cause severe cardiotoxicity related to its thyroid hormone activity, occasionally even in patients without apparent underlying cardiac abnormalities. In a large study involving men who had had a myocardial infarction, treatment with dextrothyroxine sodium was associated with a trend toward increased mortality relative to placebo. Therapy with dextrothyroxine sodium should be considered and administered cautiously in patients with risk factors for coronary artery disease, including obesity, a history of smoking, and/or a family history of premature coronary disease.

References

  1. "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company, Mount Olive, NJ.

dextrothyroxine sodium drug Interactions

There are 16 drug interactions with dextrothyroxine sodium

dextrothyroxine sodium disease Interactions

There are 5 disease interactions with dextrothyroxine sodium which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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