Dextrothyroxine sodium and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with dextrothyroxine sodium.
Dextrothyroxine Sodium High Blood Pressure (Hypertension)
Major Potential Hazard, High plausibility
dextrothyroxine - cardiovascular disease
The use of dextrothyroxine sodium is contraindicated in euthyroid patients with one or more of the following conditions: hypertension (other than mild, labile systolic hypertension); known or suspected organic heart disease, especially coronary heart disease; a history of myocardial infarction; cardiac arrhythmias or a demonstrated propensity for arrhythmias; tachycardia; rheumatic heart disease; a history of congestive heart failure; or decompensated or borderline compensated cardiac status. Dextrothyroxine sodium may cause severe cardiotoxicity related to its thyroid hormone activity, occasionally even in patients without apparent underlying cardiac abnormalities. In a large study involving men who had had a myocardial infarction, treatment with dextrothyroxine sodium was associated with a trend toward increased mortality relative to placebo. Therapy with dextrothyroxine sodium should be considered and administered cautiously in patients with risk factors for coronary artery disease, including obesity, a history of smoking, and/or a family history of premature coronary disease.
References (1)
- (2001) "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company
Dextrothyroxine Sodium Obesity
Major Potential Hazard, High plausibility
dextrothyroxine - cardiovascular disease
The use of dextrothyroxine sodium is contraindicated in euthyroid patients with one or more of the following conditions: hypertension (other than mild, labile systolic hypertension); known or suspected organic heart disease, especially coronary heart disease; a history of myocardial infarction; cardiac arrhythmias or a demonstrated propensity for arrhythmias; tachycardia; rheumatic heart disease; a history of congestive heart failure; or decompensated or borderline compensated cardiac status. Dextrothyroxine sodium may cause severe cardiotoxicity related to its thyroid hormone activity, occasionally even in patients without apparent underlying cardiac abnormalities. In a large study involving men who had had a myocardial infarction, treatment with dextrothyroxine sodium was associated with a trend toward increased mortality relative to placebo. Therapy with dextrothyroxine sodium should be considered and administered cautiously in patients with risk factors for coronary artery disease, including obesity, a history of smoking, and/or a family history of premature coronary disease.
References (1)
- (2001) "Product Information. Choloxin (dextrothyroxine sodium)." Knoll Pharmaceutical Company
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Dextrothyroxine sodium drug interactions
There are 14 drug interactions with dextrothyroxine sodium.
Dextrothyroxine sodium disease interactions
There are 5 disease interactions with dextrothyroxine sodium which include:
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More about dextrothyroxine sodium
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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