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Bromfenac / gatifloxacin / prednisolone ophthalmic and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with bromfenac / gatifloxacin / prednisolone ophthalmic which include:

Moderate

bromfenac food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSE: In-vivo studies have demonstrated that the absorption of bromfenac is greatly reduced if the drug is taken within three and one-half hours following a high fat meal. The concomitant administration of a high fat meal has led to a 75% reduction in peak plasma concentrations and a 60% reduction in total area under the curve. The mechanism has not been described.

MANAGEMENT: An increased dosage of bromfenac (from 25 to 50 mg) may be needed if a high fat meal is consumed. The clinician may want to warn the patient about subtherapeutic analgesic effects if high fat meals are regularly consumed.

References

  1. "Product Information. Duract (bromfenac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

NSAIDs - hypertension

NSAIDs including topicals can lead to the onset of new hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events. Blood pressure should be monitored closely during NSAID therapy and throughout the course of therapy.

Bromfenac / gatifloxacin / prednisolone ophthalmic drug interactions

There are 352 drug interactions with bromfenac / gatifloxacin / prednisolone ophthalmic

Bromfenac / gatifloxacin / prednisolone ophthalmic disease interactions

There are 5 disease interactions with bromfenac / gatifloxacin / prednisolone ophthalmic which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.