Drug interactions between levothyroxine and Methotrexate LPF Sodium
|Methotrexate LPF Sodium (methotrexate)|
Interactions between your drugs
- Levothyroxine is in the drug class thyroid drugs.
- Levothyroxine is used to treat the following conditions:
Methotrexate LPF Sodium
A total of 842 drugs (3840 brand and generic names) are known to interact with Methotrexate LPF Sodium.
- Methotrexate LPF Sodium is a member of the following drug classes: antimetabolites, antipsoriatics, antirheumatics, other immunosuppressants.
- Methotrexate LPF Sodium is used to treat the following conditions:
- Acute Lymphoblastic Leukemia
- Acute Lymphocytic Leukemia
- Breast Cancer
- Graft-versus-host disease
- Head and Neck Cancer
- Meningeal Leukemia
- Mycosis Fungoides
- Neoplastic Diseases
- Non-Hodgkin's Lymphoma
- Non-Small Cell Lung Cancer
- Psoriatic Arthritis
- Rheumatoid Arthritis
- Small Cell Lung Cancer
- Solid Tumors
- Systemic Sclerosis
- Trophoblastic Disease
Drug and food interactions
Applies to: Methotrexate LPF Sodium (methotrexate)
Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are receiving methotrexate for arthritis, you may want to limit your intake of caffeine-containing foods and medications. Check with your doctor or pharmacist if you have concerns or are uncertain what products may contain caffeine.
Applies to: levothyroxine
The timing of meals relative to your levothyroxine dose can affect absorption of the medication. Therefore, levothyroxine should be taken on a consistent schedule with regard to time of day and relation to meals to avoid large fluctuations in blood levels, which may alter its effects. In addition, absorption of levothyroxine may be decreased by foods such as soybean flour, cotton seed meal, walnuts, dietary fiber, calcium, and calcium fortified juices. These foods should be avoided within several hours of dosing if possible. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. When levothyroxine is given during continuous enteral nutrition (tube feedings) for more than 7 days, the tube feeding should be interrupted for at least one hour before and one hour after the dose of levothyroxine. You may need more frequent blood tests to monitor levothyroxine levels.
Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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