Drug Interactions between Entereg and Iclusig
This report displays the potential drug interactions for the following 2 drugs:
- Entereg (alvimopan)
- Iclusig (ponatinib)
Interactions between your drugs
No interactions were found between Entereg and Iclusig. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Entereg
A total of 38 drugs are known to interact with Entereg.
- Entereg is in the drug class peripheral opioid receptor antagonists.
- Entereg is used to treat the following conditions:
Iclusig
A total of 566 drugs are known to interact with Iclusig.
- Iclusig is in the following drug classes: BCR-ABL tyrosine kinase inhibitors, multikinase inhibitors, VEGF/VEGFR inhibitors.
- Iclusig is used to treat the following conditions:
Drug and food interactions
PONATinib food
Applies to: Iclusig (ponatinib)
GENERALLY AVOID: Coadministration with grapefruit juice is likely to increase the plasma concentrations of ponatinib, which is primarily metabolized by CYP450 3A4. However, the interaction has not been studied. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: The consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit extract should be avoided during treatment with ponatinib.
References
- (2012) "Product Information. Iclusig (ponatinib)." Ariad Pharmaceuticals Inc
alvimopan food
Applies to: Entereg (alvimopan)
Coadministration with a high-fat meal may decrease the rate and extent of alvimopan absorption. According to the product labeling, alvimopan peak plasma concentration (Cmax) and systemic exposure (AUC) were decreased by approximately 38% and 21%, respectively, and the time to reach peak plasma concentration (Tmax) was prolonged by approximately 1 hour when taken with a high-fat meal. The clinical significance is unknown. In postoperative ileus clinical trials, the preoperative dose of alvimopan was administered in a fasting state, and subsequent doses were given without regard to meals.
References
- (2008) "Product Information. Entereg (alvimopan)." GlaxoSmithKline
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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