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Can you take Deucravacitinib with Risa-Bid?

1 drug interaction and 11 additional warnings found for the following 2 drugs:

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Drug interactions

Moderate drug interactions

Moderate:

lactobacillus acidophilus deucravacitinib

Applies to: Risa-Bid (lactobacillus acidophilus) and deucravacitinib

If you are currently being treated or have recently been treated with deucravacitinib, you should let your doctor know before using lactobacillus acidophilus. Depending on the dose and length of time you have been on deucravacitinib, you may be at risk for developing rare infections from exposure to products containing live bacteria or yeast. Depending on your overall health and medical condition, it may be advisable to avoid using lactobacillus acidophilus until your immune system has recovered from the effects of deucravacitinib. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease interactions

11 potential interactions Applies to: 11 conditions, including Rheumatoid Arthritis, Breast Cancer, Prostate Cancer, Liver Disease, and Infection.

Bladder Cancer

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Bladder Cancer.

Malignancies including lymphomas were reported in clinical trials with deucravacitinib. Risks and benefits of each individual patient should be considered prior to treatment initiation, especially in patients with known malignancies (other than a successfully treated non-melanoma skin cancer).

Breast Cancer

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Breast Cancer.

Malignancies including lymphomas were reported in clinical trials with deucravacitinib. Risks and benefits of each individual patient should be considered prior to treatment initiation, especially in patients with known malignancies (other than a successfully treated non-melanoma skin cancer).

History, Skin Cancer

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with History, Skin Cancer.

Malignancies including lymphomas were reported in clinical trials with deucravacitinib. Risks and benefits of each individual patient should be considered prior to treatment initiation, especially in patients with known malignancies (other than a successfully treated non-melanoma skin cancer).

Immunodeficiency

Moderate:

Risa-Bid

The lactobacillus acidophilus in Risa-Bid has a moderate potential interaction with Immunodeficiency.

Probiotics, especially those containing lactobacillus, should be used with caution in immunosuppressed patients.

Infection

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Infection.

Deucravacitinib increases the risk of infection and should be avoided in patients with active or serious infections. Clinical trials also reported cases of herpes virus reactivation. Patients should be screened for viral hepatitis and tuberculosis prior to initiating therapy with this drug, and should be monitored during treatment for infection reactivations or new infections. Any new infection should be promptly diagnosed and treated and the patient should be closely monitored. If a serious infection develops, discontinue treatment immediately until the infection is treated and resolved.

Leukemia

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Leukemia.

Malignancies including lymphomas were reported in clinical trials with deucravacitinib. Risks and benefits of each individual patient should be considered prior to treatment initiation, especially in patients with known malignancies (other than a successfully treated non-melanoma skin cancer).

Liver Disease

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Liver Disease.

Deucravacitinib treatment has been associated with an increase in liver enzymes, in some cases greater than 3 times the upper normal limit (ULN). Liver enzymes should be evaluated at baseline and monitored thereafter in patients with known or suspected liver disease. If drug-induced liver injury is suspected, treatment should be interrupted until this diagnosis is excluded. Deucravacitinib is not recommended in patients with severe hepatic impairment.

Lung Cancer

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Lung Cancer.

Malignancies including lymphomas were reported in clinical trials with deucravacitinib. Risks and benefits of each individual patient should be considered prior to treatment initiation, especially in patients with known malignancies (other than a successfully treated non-melanoma skin cancer).

Lymphoma

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Lymphoma.

Malignancies including lymphomas were reported in clinical trials with deucravacitinib. Risks and benefits of each individual patient should be considered prior to treatment initiation, especially in patients with known malignancies (other than a successfully treated non-melanoma skin cancer).

Prostate Cancer

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Prostate Cancer.

Malignancies including lymphomas were reported in clinical trials with deucravacitinib. Risks and benefits of each individual patient should be considered prior to treatment initiation, especially in patients with known malignancies (other than a successfully treated non-melanoma skin cancer).

Rheumatoid Arthritis

Moderate:

deucravacitinib

Deucravacitinib has a moderate potential interaction with Rheumatoid Arthritis.

A large, randomized, postmarketing safety trial of a JAK inhibitor in rheumatoid arthritis (RA) patients 50 years old and older with at least one cardiovascular risk factor, reported higher rates of all-cause mortality, including sudden cardiovascular death, major adverse cardiovascular events, overall thrombosis, deep venous thrombosis, pulmonary embolism, and malignancies (excluding non-melanoma skin cancer) in patients treated with the JAK inhibitor compared to patients receiving TNF blockers. Deucravacitinib is not approved for use in RA.

More resources

deucravacitinib

A total of 545 drugs are known to interact with deucravacitinib.

Risa-Bid

A total of 370 drugs are known to interact with Risa-Bid.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.