Drug Interactions between Biltricide and clarithromycin
This report displays the potential drug interactions for the following 2 drugs:
- Biltricide (praziquantel)
- clarithromycin
Interactions between your drugs
No interactions were found between Biltricide and clarithromycin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Biltricide
A total of 102 drugs are known to interact with Biltricide.
- Biltricide is in the drug class anthelmintics.
-
Biltricide is used to treat the following conditions:
- Beef Tapeworm Infection
- Cysticercus cellulosae
- Dog Tapeworm Infection
- Dwarf Tapeworm Infection
- Echinococcus
- Fasciolopsis buski, Intestinal Fluke
- Fish Tapeworm Infection
- Heterophyes heterophyes, Intestinal Fluke
- Liver Fluke
- Metagonimus yokogawai, Intestinal Fluke
- Naophyetus salmincola
- Opisthorchis viverrini, Liver Fluke
- Paragonimus westermani, Lung Fluke
- Pork Tapeworm Infection
- Schistosoma haematobium
- Schistosoma japonicum
- Schistosoma mansoni
- Schistosoma mekongi
clarithromycin
A total of 684 drugs are known to interact with clarithromycin.
- Clarithromycin is in the drug class macrolides.
-
Clarithromycin is used to treat the following conditions:
- Bacterial Endocarditis Prevention
- Bronchitis
- Dental Abscess
- Follicular Lymphoma (off-label)
- Helicobacter Pylori Infection
- Legionella Pneumonia
- Mycobacterium avium-intracellulare, Prophylaxis
- Mycobacterium avium-intracellulare, Treatment
- Mycoplasma Pneumonia
- Nongonococcal Urethritis
- Otitis Media
- Pertussis
- Pertussis Prophylaxis
- Pharyngitis
- Pneumonia
- Sinusitis
- Skin and Structure Infection
- Skin or Soft Tissue Infection
- Strep Throat
- Tonsillitis/Pharyngitis
- Toxoplasmosis
- Upper Respiratory Tract Infection
Drug and food interactions
praziquantel food
Applies to: Biltricide (praziquantel)
ADJUST DOSING INTERVAL: Administration with food increases the oral bioavailability of praziquantel. The mechanism has not been described. In nine healthy volunteers, administration of praziquantel (1800 mg single oral dose) following a high-fat meal increased the mean praziquantel peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 243% and 180%, respectively, compared to administration under fasting conditions. Administration with a high-carbohydrate meal increased these values by 515% and 271%, respectively, compared to fasting. Overall, the relative bioavailability was increased by a factor of 2.72 and 3.98 with the high-fat and high-carbohydrate meals, respectively. The time to reach peak concentration (Tmax) and elimination half-life (T1/2) were not significantly altered.
Coadministration with grapefruit juice may increase the oral bioavailability of praziquantel. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall induced by certain compounds present in grapefruit. In 18 healthy volunteers, administration of praziquantel (1800 mg single oral dose) with 250 mL of commercially squeezed grapefruit juice resulted in increases in the mean praziquantel Cmax and AUC of 63% and 90%, respectively, compared to administration with water. The Tmax and T1/2 were not significantly altered. The pharmacokinetics of praziquantel were subject to a high degree of interpatient variability with and without grapefruit juice.
MANAGEMENT: To ensure maximal oral absorption, praziquantel should be administered with meals. Administration with grapefruit juice may further increase pharmacologic effects of praziquantel, including adverse effects such dizziness, abdominal discomfort, and nausea.
References
- Castro N, Jung H, Medina R, Gonzalez-Esquivel D, Lopez M, Sotelo J (2002) "Interaction between grapefruit juice and praziquantel in humans." Antimicrob Agents Chemother, 46, p. 1614-6
- Castro N, Medina R, Sotelo J, Jung H (2000) "Bioavailability of praziquantel increases with concomitant administration of food." Antimicrob Agents Chemother, 44, p. 2903-4
clarithromycin food
Applies to: clarithromycin
Grapefruit juice may delay the gastrointestinal absorption of clarithromycin but does not appear to affect the overall extent of absorption or inhibit the metabolism of clarithromycin. The mechanism of interaction is unknown but may be related to competition for intestinal CYP450 3A4 and/or absorptive sites. In an open-label, randomized, crossover study consisting of 12 healthy subjects, coadministration with grapefruit juice increased the time to reach peak plasma concentration (Tmax) of both clarithromycin and 14-hydroxyclarithromycin (the active metabolite) by 80% and 104%, respectively, compared to water. Other pharmacokinetic parameters were not significantly altered. This interaction is unlikely to be of clinical significance.
References
- Cheng KL, Nafziger AN, Peloquin CA, Amsden GW (1998) "Effect of grapefruit juice on clarithromycin pharmacokinetics." Antimicrob Agents Chemother, 42, p. 927-9
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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