Drug Interactions between atropine / phenobarbital and phenobarbital
This report displays the potential drug interactions for the following 2 drugs:
- atropine/phenobarbital
- phenobarbital
Interactions between your drugs
No interactions were found between atropine / phenobarbital and phenobarbital. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
atropine / phenobarbital
A total of 855 drugs are known to interact with atropine / phenobarbital.
- Atropine / phenobarbital is in the drug class anticholinergics/antispasmodics.
phenobarbital
A total of 785 drugs are known to interact with phenobarbital.
- Phenobarbital is in the following drug classes: barbiturate anticonvulsants, barbiturates.
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Phenobarbital is used to treat the following conditions:
- Epilepsy
- Hyperbilirubinemia (off-label)
- Insomnia (off-label)
- Sedation
- Seizures
Drug and food interactions
PHENobarbital food
Applies to: atropine / phenobarbital and phenobarbital
GENERALLY AVOID: Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these agents may occur with chronic use. The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.
MANAGEMENT: The combination of ethanol and barbiturates should be avoided.
References
- Gupta RC, Kofoed J (1966) "Toxological statistics for barbiturates, other sedatives, and tranquilizers in Ontario: a 10-year survey." Can Med Assoc J, 94, p. 863-5
- Misra PS, Lefevre A, Ishii H, Rubin E, Lieber CS (1971) "Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats." Am J Med, 51, p. 346-51
- Saario I, Linnoila M (1976) "Effect of subacute treatment with hypnotics, alone or in combination with alcohol, on psychomotor skills related to driving." Acta Pharmacol Toxicol (Copenh), 38, p. 382-92
- Stead AH, Moffat AC (1983) "Quantification of the interaction between barbiturates and alcohol and interpretation of fatal blood concentrations." Hum Toxicol, 2, p. 5-14
- Seixas FA (1979) "Drug/alcohol interactions: avert potential dangers." Geriatrics, 34, p. 89-102
atropine food
Applies to: atropine / phenobarbital
GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
References
- Linnoila M (1973) "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol, 6, p. 107-12
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Tranquilizers
Therapeutic duplication
The recommended maximum number of medicines in the 'tranquilizers' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'tranquilizers' category:
- atropine/phenobarbital
- phenobarbital
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Barbiturates
Therapeutic duplication
The recommended maximum number of medicines in the 'barbiturates' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'barbiturates' category:
- atropine/phenobarbital
- phenobarbital
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Barbiturate anticonvulsant agents
Therapeutic duplication
The recommended maximum number of medicines in the 'barbiturate anticonvulsant agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'barbiturate anticonvulsant agents' category:
- atropine/phenobarbital
- phenobarbital
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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